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In patients that met the NIT criteria, the following reasons were exclusionary from treatment with resmetirom based on the histological findings: 34 (9.3%) had cirrhosis on biopsy (F4), 117 (32.0%) had F0-F1, and 70 (19.1%) had F2-F3 but NAS 30% was defined as unreliable

Because of this, people often feel they need to take very high doses to see any change

Since individual response to the medication varies, adjustments should be made under the guidance of a healthcare provider

Upon addition of ME, the olefinic proton (H a ) of TPE-DCV with chemical shift of ~8.4 ppm disappears and a new peak (H b ) at 4.69 ppm arises, suggestive of the addition reaction of thiol on the vinyl group (Figure S6) 58