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More severe disease at onset in the form of a higher number of symptoms ( Several studies have also suggested that factors relating to the initial immune response to infection may drive later clinical outcomes after treatment

"Novel Peptide Therapeutics for Weight Management and Metabolic Disease." The Lancet Diabetes & Endocrinology, 11(2), 123-138

18 The treatment protocol for TPE consists of removing and retaining a considerable volume of plasma, approximately 1 to 1.5 plasma volume, 17 and returning the necessary cellular components via a colloid or combination colloid/crystallization solution of either fresh frozen plasma (FFP) or albumin