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To confirm our observation of low B12-induced FAO impairment in AT, we assessed mitochondria functional integrity in a preadipocyte cell line and primary adipocytes, and the correlation of B12 with FAO genes in mature human scWAT and omWAT

Potential tumor promotion : Given its angiogenic properties, there is theoretical concern it could contribute to tumor growth or neovascularization in certain contexts

The absence of FDA approval means no verified manufacturing standards, dosing protocols, or safety benchmarks exist for human use

Most ALPS patients are affected by heterozygous germline mutations in the Fas cell surface death receptor gene ( FAS ) via autosomal dominant inheritance (Jackson et al., 2010)