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The knock-on effects are powerful once you realize that this system is tasked with cell birth/death in the brain: Priming could also prevent microglia from exerting their normal physiological functions, directly impairing neurogenesis, synaptogenesis, and the wiring of brain circuits, with severe impacts on learning, memory and other cognitive processes

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10.1093/bja/68.6.613 203 MurrellG