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Ann Thorac Surg 91(3):770-6, 2011

While approximately 75% of cases remain idiopathic, accumulating evidence from clinical and molecular studies has elucidated several key non-iatrogenic factors that contribute to spontaneous POI onset, encompassing genetic, autoimmune, infectious, environmental, and metabolic domains [93]

ULD: ubiquitin-like domain

Increasing the size of Nano-Bc than Nano-Lut and less negative zeta potential may be additional reasons for Nano-Lut giving better results as a treatment for our animal model