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A deficiency can lead to a type of anemia that causes pale skin and shortness of breath

During the oxidative phase, glucose 6-phosphate is converted to NADPH and ribose 6-phosphate

2.2.3 Others Metformin influences the production of advanced glycation end products (AGEs) and the generation of ROS through the activation of AMPK, inhibition of the receptor for advanced glycation end products/nuclear factor kappa B (RAGE/NF-B) signaling pathway, and modulation of gene expression

Research indicates that the leakage of iron is associated with neurodegeneration and may exacerbate pathological conditions by inducing inflammatory responses and cellular damage ( During ferroptosis, the deficiency of GPX4 leads to elevated levels of intracellular ROS, triggering oxidative stress (Zheng and Conrad, 2020)