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Furthermore, genome-wide CRISPR screening identified SEC24 homolog B (SEC24B) as a key regulator of ferroptosis, and its knockout significantly inhibited ferroptosis in microglia (Ryan et al., 2023b)

However, given that muc5AC is increased and muc5B decreased in the sputum obtained from asthmatics [48], it is possible (although speculative) that tachykinins have stimulatory roles on muc5AC, but inhibitory roles on muc5B