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Cullin binding to substrates and E2-ubiquitin conjugating enzymes is indirect

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Wise DR, et al

In addition, abnormal activation of the PI3K/Akt pathway mediates the expression of ABC transporters, which increases drug efflux and reduces drug response through up-regulation of P-gp, BCRP, and MRP1 expressions, thus leading to chemoresistance (107)