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While the treatment for pruritus stemming from cholestatic liver disorders is established, pruritus originating from non-cholestatic causes is frequently encountered in cirrhotic patients due to various non-cholestatic factors

doi: 10.1016/j.drup.2017.05.002 169 LeiHPeiZJiangCChengL

Numerous challenges still need to be overcome before nanotechnology can be used in clinical practice, such as ensuring the biosafety of nanomaterials, optimizing drug loading and release mechanisms, and facilitating large-scale production