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4528-C A HETEROGENEOUS SUBTYPE OF BILIARY EPITHELIAL SENESCENCE MAY BE INVOLVED IN THE PATHOGENESIS OF PRIMARY BILIARY CHOLANGITIS Motoko Sasaki 1 , Yasunori Sato 1 and Yasuni Nakanuma 2 , (1)Kanazawa University Graduate School of Medical Sciences, (2)Fukui Saiseikai Hospital Background: We disclosed an involvement of biliary epithelial senescence in the pathogenesis of primary biliary cholangitis (PBC) and other cholangiopathies