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All findings cited are from in vitro (cell culture) or preclinical (animal model) studies unless stated otherwise

doi: 10.1016/j.autrev.2020.102664

Morizane R, Lam AQ, Freedman BS, Kishi S, Valerius MT, Bonventre JV (2015) Nephron organoids derived from human pluripotent stem cells model kidney development and injury

Lipid peroxidation mainly includes the reaction of ROS with lipid molecules in cell membranes, raising membrane fluidity and permeability, thereby having an impact on cell structure and function ( Moreover, DNA damage activates stress response mechanisms within cells, possibly causing apoptosis or mutation, further compromising the health of gingival tissues ( 2.3.3 Depletion of antioxidant systems During the prolonged progression of chronic periodontitis, oxidative stress persists, causing depletion and imbalance of antioxidant systems ( 3 Antioxidants and their roles 3.1 Types and functions of main antioxidants Antioxidants are compounds which is capable of neutralizing and clearing oxygen free radicals and other oxidants within cells, having a huge impact on the prevention and treatment of chronic inflammatory diseases