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We speculate that GlyNAC represents three forces which could be operating simultaneously to result in such widespread improvements: (1) Correction of GSH deficiency, which results in correction of OxS and mitochondrial dysfunction

Keywords: A and oxidative damage, Alzheimer disease and lipid peroxidation and protein oxidation, Alzheimer disease and translational approaches, Down syndrome and Alzheimer disease and oxidative stress, oxidative stress and energy dysmetabolism Abstract Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms, among which oxidative stress (OS) appears as a major determinant

doi: 10.3892/ijmm 505 MikeczAVKonstantinovKBuchwaldDSGeraceLTanEM