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Loss of epigenetic control of synuclein-gamma gene as a molecular indicator of metastasis in a wide range of human cancers

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During reaction with disulfides in oxidized proteins, Trx and Grx become oxidized and subsequently reduced again by NADPH-dependent thioredoxin reductase or the low-molecular-weight thiol glutathione (GSH), respectively, to regenerate the active form of these enzymes