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10.1016/j.biomaterials.2016.09.010 82 NazroluM.CiB.OzglC

In the bloodstream, the concentration of Cu is typically maintained at a level of 0.71.4 g/mL (Cartwright and Wintrobe, 1964), most Cu is bound to ceruloplasmin (Cp), while a smaller fraction is associated with albumin, transferrin, and free amino acids, and is transported to the liver via the portal venous system (Kirsipuu et al., 2020

Experimental studies in animal models have demonstrated that disruption of opioid receptor-mediated neurotransmission leads to a reduction in social behaviors (Ragen et al