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An approved drug that inhibits NADH:ubiquinone oxidoreductase is the biguanide metformin 41 , the first-line treatment in type II diabetes 41

Thu Le, N.N

Moreover, ketone bodies are also important in the synaptic vesicular cycle (41), KD can also affect neurotransmitter levels in the synaptic cleft and increase GABA levels in addition to altering glutamate metabolism (42)