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These programs actively suppress immune surveillance by competing with effector lymphocytes for glucose and amino acids, secreting lactate to acidify the TME, and generating adenosine via CD39/CD73 to blunt T cell and NK cell activity

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Therefore, the updating of vaccines needs to keep pace with the times to avoid another pandemic with an unpredictable new variant. Co-authors of the study include Yao Ma (first author), Ye Wang, Chunhong Dong, Gilbert X