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For older adults on long-term PPIs, periodic B12 monitoring is appropriate and a daily sublingual methylcobalamin is a reasonable preventive measure to discuss with the prescriber

3.6 Cuprizone-induced demyelination triggers lasting morphological changes in astrocytes To assess whether regional myelin remodeling parallels astrocytic remodeling, brain cryosections were immunolabeled for GFAP ( Figure 6A )