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PATINA: IBRANCE in Combination with Trastuzumab, with or without Pertuzumab, and Endocrine Therapy (Fulvestrant or Aromatase inhibitors [Anastrozole, Letrozole or Exemestane]) Patients with HR-positive, HER2-positive locally advanced or metastatic breast cancer after induction therapy

This prolonged activation makes it powerful, but also requires a more thoughtful approach to timing and dosing

Convenience: Oral supplements are easy for daily use, while injections offer targeted, professionally administered solutions

The solvents were removed in vacuo and the crude product purified by flash column chromatography (1% triethylamine (TEA), 10% MeOH in EtOAc) to obtain 3 (446 mg, 95%) as an orange oil