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118 Research indicates that APOE protein is detectable in neuritic plaques, and individuals with the APOE4 allele also have a higher burden of A plaques in their brains, 119,120 highlighting its critical influences on A deposition

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Catalytic Residues Roles Chemical Components ingold: aromatic unimolecular elimination by the conjugate base, enzyme-substrate complex cleavage, intermediate collapse, intermediate terminated, native state of cofactor regenerated Catalytic Residues Roles Chemical Components proton transfer Step 5