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Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)

A careful comparison of our eosinophil dataset with previous bulk RNA-seq data (Wang et al., 2022) and the limited number of published scRNA-seq profiles of eosinophils (Chhiba and Kuang, 2024

10.25177/jps.1.1.2 56 FloresR.InselP

Abstract Aim: To investigate the mechanisms underlying the protective effects of quercetin-rutinoside (rutin) and its aglycone quercetin against CCl 4 -induced liver damage in mice