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In this regard, a key mode of action to explain this relationship is via glucose transporter type 1 (GLUT1) which increases uptake of the oxidized form of ascorbic acid, dehydroascorbate and subsequently depletes glutathione (Yun et al., 2015)

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Additionally, urolithins can regulate cholesterol metabolism by reducing the abundance of Coriobacteriaceae bacteria and altering the bile acid pool, thereby promoting lipid absorption in the intestines and providing cardiovascular protection ( FIGURE 2 Upon entering the human body, ellagitannins undergo bidirectional modulation with the gut microbiota