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For example, MMP-9, produced by both AECs and Thy-1-negative fibroblasts, not only activates TGF- to sustain a profibrotic cycle but also enhances fibroblast migration and collagen deposition ( + /collagen + bone marrow-derived cellsexploit the proteolytic activity of MMP-2, MMP-8, and MMP-9 to degrade ECM barriers, facilitating their migration into lung tissue and subsequent differentiation into myofibroblasts ( However, paradoxically, certain MMPs demonstrate context-dependent antifibrotic potential, suggesting protective roles under specific conditions

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The Epstein-Barr virus (EBV) deubiquitinating enzyme BPLF1 reduces EBV ribonucleotide reductase activity

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