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The observed skeletal benefits have been linked to combined effects on vascular development and regulation of growth factor-mediated pathways involved in bone remodeling

FOXO4-DRI has been investigated extensively in preclinical academic literature for p53 transactivation domain binding, senescence-associated apoptosis pathway research, p16 and IL-6 marker dynamics in senescent cell research models, and SASP (senescence-associated secretory phenotype) signaling