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Description

With latent TGF- being tethered to ECM or cell membrane (through the binding of LAP to LTBP, GARP, or LRRC33 as mentioned before) and the cytoplasmic domain of integrin 6 subunit linking to the actin cytoskeleton, V6 integrin can transmit contractile force which changes the conformation of LAP to release TGF- ligand