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SFN induces a pro-oxidative milieu in untransformed human T-cells ROS are ubiquitously generated and recognized as important signaling molecules for T-cell activation, but excessive ROS generation or prolonged exposure to high ROS concentrations impair T-cell functions ( 2 DCFDA and treated with SFN prior to flow cytometric analysis

Experimental evidence has shown that a sulfhydryl group (-SH) attached to cysteine does not easily exchange its proton with a deuteron from the water (Rozman 2005)

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Clinically, these benefits are evidenced in NO inhalation therapy for neonatal respiratory disorders, such as persistent pulmonary hypertension, and in ozone (O 3 ) or hyperbaric oxygen (HBO) therapy for degenerative spinal conditions