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At the AACR 2026, a poster presented by Crown Bioscience demonstrated how genOways hSA/hFcRn mice (genO-hSA/hFcRn), enable a predictive, humanrelevant PK assessment of ADCs across diverse linker and payload formats, showing how this model could be an alternative to replace the use of non-human primates (NHPs)

Proteins were electrotransfered to PVDF membranes (Millipore, Billerica, MA), which were blocked by a 1-h incubation with Tris-buffered saline (TBS) containing 0.1% Tween-20 and 5% non-fat milk at room temperature

Br J Dermatol 173(6):13871399

What This Means and What It Doesn''t There are important things this trial can and cannot establish