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Friedreich ataxia: current state-of-the-art, and future prospects for mitochondrial-focused therapies

Choi GE, Oh JY, Lee HJ, Chae CW, Kim JS, Jung YH, Han HJ (2018) Glucocorticoid-mediated ER-mitochondria contacts reduce AMPA receptor and mitochondria trafficking into cell terminus via microtubule destabilization

Recent studies on phase 1 clinical trials using, Elamipretide, a mitochondrial-targeted drug, have shown a positive effect on visual function without adverse effects (Mettu et al., 2022)