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DAMPs have been found to link with the pathogenesis of chronic metabolic diseases or disorders [238]

Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution

(118) found 40 studies published between 2012 and 2020 that were eligible for qualitative review, with a subset of 22 studies that were considered eligible for inclusion in the meta-analysis

These antioxidant effects are thought to be mediated through a dual mechanism: indirectly, by improving systemic metabolism and cardiac energy efficiency (Usman et al., 2024), and more directly, through the inhibition of myocardial NOX2 expression and the activation of endogenous antioxidant pathways such as Nrf2(Preda et al., 2024)