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10.1016/j.biotechadv.2017.12.015 Biotechnol

o S en una posicin que corresponde a la posicin 196 E en una posicin que corresponde a la posicin 420 y E en una posicin que corresponde a la posicin 424, con referencia a las posiciones de aminocidos que se muestran en la SEQ ID For example, between the modified FX polypeptides or the isolated modified FX polypeptides described herein, including any described above, are the FX polypeptides that contain an (s) substitution (s) of amino acid (s): S in a position corresponding to position 196, S in a position corresponding to position 211 and H in a position corresponding to position 219