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Am J Kidney Dis (2021) 77(2):2806

Gut microbiome-produced bile acids influence glucose and lipid metabolism, energy balance, and inflammation via FXR and TGR5 receptor signaling, thus, alterations in bile acid profiles may disrupt these pathways and contribute to metabolic disease [219]

This molecule is important for neutralizing free radicals, supporting liver detoxification, and maintaining optimal immune and cellular health

2d, g), which suggests that the mitochondria of these particular cells are far less insulated from the pro-ferroptotic oxidative stress induced by cystine starvation (Fig