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In MS, clinical therapies aimed to block TNF--mediated pro-inflammatory effects (Van Oosten et al., 1996

Intraventricular injection of CNTF in EAE mice reduced expression of inflammatory cytokines TNF- and interferon- and decreased demyelination and neurodegeneration (117)

4B) is consistent with a scenario in which the elevated ROS levels by c-SRC activation are squelched by augmented PPP under glucose deprivation and with a lactic acid signaling