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In Studies JMEN, PARAMOUNT, and JMEI, where all patients received vitamin supplementation, incidence of Grade 3-4 neutropenia ranged from 3% to 5%, and incidence of Grade 3-4 anemia ranged from 3% to 5%

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(GA image) The upper mixed layer is all one temperature but that temperature can vary from -2 degrees C, at the poles, to +30 degrees C, in the tropics

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