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T., and Maltese W

Therefore, how to ensure treatment effectiveness while minimizing damage to normal brain tissue has become an important research direction in the field of radiation therapy

Ferroptosis can therefore be induced by depriving cells of the sulfur-containing GSH precursor, cysteine, via inhibition of the system x c cystine/glutamate antiporter (e.g., using small molecules of the erastin family), or by direct inhibition of GPX4 itself (Forcina & Dixon, 2019)