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Split vertical bars represent combined clinical presentation (adapted from Ref.44, 3rd ed.)

To assess the amphetamine exposure-effect relationship, the changes in pharmacodynamic effect after lisdexamfetamine and D-amphetamine administration for each time point were plotted against the respective plasma concentrations of amphetamine (hysteresis plots)

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

Because of this origin, researchers study it in laboratory work on tissue repair and cell protection