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DO NOT use antidiabetics to achieve hemoglobin A1c less than 7.5% in most older adults

LIN28A/B repress the maturation of the let-7 family of microRNAs consisting of nine ( a, b, c, d, e, f, g, i and miR-98 ) functionally redundant microRNAs that originate from eight conserved let-7 microRNA expressing clusters in humans and mice 14,15,16,17,18