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Description

These reactive molecules have a signaling function, modifying the Keap1 protein, which leads to Nrf2 activation (124)

10.1371/journal.pone.0092842 55

Ishii T, Shimpo Y, Matsuoka Y, Kinoshita K

First-line inavolisib/placebo + palbociclib + fulvestrant (Inavo/Pbo+Palbo+Fulv) in patients (pts) with PIK3CA-mutated, hormone receptor-positive, HER2negative locally advanced/metastatic breast cancer who relapsed during/within 12 months (mo) of adjuvant endocrine therapy completion: INAVO120 Phase III randomized trial additional analyses