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doi: 10.3389/fnut.2025.1581848 Received 23 February 2025 Accepted 22 September 2025 Published 15 October 2025 Volume 12 - 2025 Edited by Roberta Zupo, University of Bari Aldo Moro, Italy Reviewed by Padhmanand Sudhakar, Kumaraguru College of Technology, India Edem E

Folate, vitamin B6, and vitamin B12 all play major roles in lowering homocysteine by converting it to methionine

Folate (Vitamin B9) Another of the B vitamins depleted by alcohol is the mighty folate (B9), with deficiency reported in up to 80% of alcoholics

Brain fog Headaches Fatigue Moodiness and irritability Bloating Diarrhea or constipation Joint pain Nausea Skin issues Flu-like symptoms You are more likely to experience die-off symptoms if your detox pathways are compromised (e.g., if you have an MTHFR mutation)