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doi: 10.1126/science.1223490 88 ONeilLJOliveiraCBWangXNavarreteMBarrera-VargasAMerayo-ChalicoJet al

Together these findings, therefore, suggest that alsin protects cells from oxidative stress and could be a redox sensing protein, similar to Rab5, Rac1, and SOD1

Mechanistically, CB-839 elevates the levels of intracellular ROS, enhances the movement of Nrf2 into the nucleus, leading to an increase in uridine phosphorylase 1 (UPP1) mRNA expression