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In p53 + / + trophoblasts, erastin-induced ROS elevation was more pronounced than that in p53 / and control cells, and angiogenesis was impaired

8 Both the 2012 NIH Evidence-Based Methodology Workshop on PCOS and the 2018 International Evidence-Based Guideline for the Assessment and Management of Polycystic Ovary Syndrome recommend use of the Rotterdam criteria for the diagnosis of PCOS with the additional identification of the specific PCOS phenotype

ATF3 participates in various aspects of ferroptosis, influencing iron metabolism and lipid processing, and modifying cellular antioxidant defense mechanisms (114116)

Furthermore, thiazolidinedione derivatives (e.g., rosiglitazone and pioglitazone) demonstrate selective inhibition of ACSL4, consequently attenuating ferroptosis progression (Sheng et al., 2024)