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Science 354 , 472477 (2016)

This was an unexpected result insofar that GPX3 is considered a classical Nrf2-induced gene and TNF- has repeatedly been reported to upregulate other Nrf2 target genes in various cell types including leukocytes of the myeloid lineage, vascular endothelial cells, and osteoblasts 50,51,52,53,54

17 Dietary manipulations through dietary restriction and supplementation with folic acid and antioxidants (e.g., N-acetylcysteine, acetyl-L-carnitine, alpha-lipoic acid, glutathione, Ginkgo biloba ) to promote successful brain aging are being studied