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Key gaps to address: dose-response in humans, safety/tolerability profiles across populations, interaction effects in stacks, and long-term cardiometabolic outcomes

Other aspects of the vegan diet are healthy but, said Sanders, B12 is the one thing we are concerned about

If menstrual irregularity develops or worsens after initiating the stack, measure luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and thyroid function