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While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease

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Int Immunopharmacol 14(2):209216 Choy KW, Murugan D, Leong XF, Abas R, Alias A, Mustafa MR (2019) Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFB) signaling in cardiovascular diseases: a mini review