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Iron-killed tumor cells may release specific proteins (such as those encoded by the K-RasG12D gene) that are mediated by RAGE, which polarizes macrophages to the M2 phenotype through the signal transducer and activator of transcription 3 (STAT3) fatty acid oxidation pathway (187)

J Appl Pharm Res 8(1):2943 Sharma K, Verma R, Kumar D, Nepovimova E, Kua K, Kumar A, Raghuvanshi D, Dhalaria R, Puri S (2022) Ethnomedicinal plants used for the treatment of neurodegenerative diseases in Himachal Pradesh, India in Western Himalaya

The authors established FOXO4-DRI as a first-in-class senolytic peptide tool for cellular senescence research, with mechanistic selectivity grounded in the elevated FOXO4-p53 interaction in senescent versus non-senescent cells