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Naively, one would expect from the Ramachandran plot that the DRI-fibrils have a twist angle which is of opposite sign but equal magnitude than the one seen in the corresponding L-fibrils

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Further, NOX2 depletion and the NOX inhibitor apocynin were able to reduce NF-KB activation, demonstrating how ROS can lead to the increased expression of proinflammatory cytokines (Shekh-Ahmad et al., 2019, 2018)