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177 YangJ.ShiX.WangY.MaM.LiuH.WangJ.et al (2023)

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While a number of APAP overdose cases are due to suicide attempts, the availability of combination products, where the presence of APAP may not be easily recognized, has led to an increase in unintentional and chronic APAP overdose, accounting for over 50% of cases of APAP-related ALF4

The method of claim 56, wherein the set of variant nucleic acids is generated by performing amplification reactions on the nucleic acid of step (a) using the set of oligonucleotides to generate a set of variant nucleic acids encoding nineteen amino acid substitution variants at a single amino acid residue of the antigen-binding polypeptide