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For instance, drugs like regorafenib impede cancer cell signaling by suppressing tyrosine kinase activity, while tamoxifen and others curb cancer cell growth and metabolism by inhibiting the mammalian target of rapamycin (mTOR) pathway [98, 99]

Ferroptosis may explain the clinical phenomenon that severe COVID-19 patients without a background of renal disease nevertheless develop renal dysfunction or impairment (Cheng et al., 2020)