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There was no effect on fertility in male or female rats following administration of tesamorelin acetate at doses up to 0.6 mg/kg (approximately equal to clinical exposure) for 28 days in males or 14 days in females

Though women are more likely to experience bone loss with age than men, men can still be at risk, particularly if they: have low testosterone levels, smoke, have digestive disorders, or abuse alcohol

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This peripheral Th1 bias is associated with enhanced central inflammatory responses and may exacerbate the neuroinflammatory state in patients with epilepsy (Sharifi et al., 2023)