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However, long-term use of cyclosporine may impart the chronic inflammation which may further induce irreversible tubulo-interstitial fibrosis and scarring in cortico-medullary area by profibrogenic mediators such as TGF-.128 Kumar et al

34 In clinical studies involving both animals and humans, a special preparation of Coleus forskohlii, applied directly to the eye, was shown to reduce IOP by increasing intraocular circulation and decreasing aqueous humor inflow into the posterior cavity

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In a research setting, the powder is prepared by gently adding water and storing the solution cold, while the unopened vials are kept frozen