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Interestingly, another mechanism was proposed as an alternative way to stabilize NRF2 through the interaction between the autophagy adaptor protein p62/sequestosome-1 (p62/SQSTM1) and KEAP1, which leads to the sequestration of KEAP1 in the autophagy-deficient cells and enables NRF2 accumulation [20]

"Physiological regulation of the human growth hormone (GH)insulin-like growth factor type I (IGF-I) axis: predominance of pulsatile GH secretion and role of IGF-I feedback." Endocr Rev