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The shelf life varies by specific product, and all medications should be used before the expiration date printed on the packaging when stored according to the manufacturer's instructions: Semaglutide (Ozempic, Wegovy) : Unopened pens may be stored in the refrigerator until the expiration date on the label Dulaglutide (Trulicity) : Remains stable when refrigerated until the printed expiration date Liraglutide (Victoza, Saxenda) : Maintains potency when refrigerated continuously until expiration Tirzepatide (Mounjaro, Zepbound) : Stable under refrigeration until the manufacturer's expiration date Exenatide (Byetta, Bydureon BCise) : Requires refrigeration and remains effective until expiration when stored properly It is important to note that permitted room-temperature storage periods as specified in the prescribing information do not invalidate the expiration date

Acknowledgements The work was supported by a NHLBI grant R01HL148112 (L.S.), two Stimulating and Advancing ACCM Research (StAAR) grants from the Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University (L.S

This allows the body to safely clear toxic homocysteine while maintaining a continuous, sustainable supply of cysteine for ongoing antioxidant defense